Sinitsyn M V, Bogadel'nikova I V, Sokolova G B
Probl Tuberk Bolezn Legk. 2007(4):21-5.
Drug resistance in Mycobacterium tuberculosis, adverse reactions, caused by antituberculous drugs, as well as suppressed cellular immunity are responsible for lower efficiency of treatment. To improve the results of treatment in patients with tuberculosis in the intensive phase, the authors used glutoxim, a representative of thiopoeitins. Glutoxim treatment was performed in 73 patients with pulmonary tuberculosis (a study group). A control group comprised 45 patients. The course of therapy with glutoxim, 60 mg/day, was 52 days. The study group was characterized by a rapider cessation of intoxication symptoms, the higher rates of bacterial isolation cessation, and decay cavity-closure. At the end of an intensive treatment, there was abacillarity in 64 (86.7%) patients from the study group and in 32 (71.1%) control patients; decay cavity closure was observed in 60 (88.3%) and 29 (70.8%) patients, respectively (p < 0.05).
结核分枝杆菌的耐药性、抗结核药物引起的不良反应以及细胞免疫抑制导致治疗效果降低。为提高肺结核患者强化期的治疗效果，作者使用了硫代乙内酰脲类药物的代表——谷胱甘肽。对73例肺结核患者（研究组）进行了谷胱甘肽治疗。对照组包括45例患者。谷胱甘肽的治疗疗程为每天60毫克，共52天。研究组的特点是中毒症状更快消失、细菌培养转阴率更高以及空洞闭合。强化治疗结束时，研究组64例（86.7%）患者和对照组32例（71.1%）患者痰菌转阴；分别有60例（88.3%）和29例（70.8%）患者的空洞闭合（p<0.05）。
