Livanov G A, Moroz V V, Batotsirenov B V, Lodiagin A N, Andrianov A Iu, Bazarova V G
Anesteziol Reanimatol. 2003 Mar-Apr(2):51-4.
The multi-factor effect of pharmacological preparations reamberine and citotoflavine, which contain succinate, in critical conditions is preconditioned by the impact they produce on a total energy deficit caused by a long-term hypoxia. The correction of energy deficit improves the therapy of patients in coma, which resulted from poisonings by neurotropic substances. The therapeutic effect manifested itself through a shorter state of coma from 25 to 12.5%. However, an analysis of died patients, who received the metabolic antihypoxants, showed that these drugs are not effective, when the time lapse from poisoning to medical aid exceeded 20 hours. When perftoran, a corrector of oxygen transport, and antihypoxant cytoflavin were added to the therapy scheme, it resulted in that 22 of 24 patients, who were also taken to clinic in the state of coma after 20 and more hours, survived, while all patients in the comparison group (20 patients) died despite an intensive therapy.
含有琥珀酸盐的药物制剂雷胺菌素和细胞黄素在危急情况下的多因素作用，是由它们对长期缺氧导致的总能量不足所产生的影响预先决定的。能量不足的纠正改善了因神经毒性物质中毒而昏迷的患者的治疗效果。治疗效果表现为昏迷状态从25%缩短至12.5%。然而，对接受代谢性抗缺氧剂治疗的死亡患者的分析表明，当中毒至医疗救助的时间间隔超过20小时时，这些药物无效。当将氧转运校正剂珀氟醇和抗缺氧剂细胞黄素添加到治疗方案中时，结果是24名在20小时及更长时间后也处于昏迷状态被送往诊所的患者中有22名存活，而对照组的所有患者（20名）尽管接受了强化治疗仍死亡。
