Ter Arkh. 2011;83(10):58-61.
To examine efficacy of a substrate antihypoxic drug reamberine in patients with cerebral insufficiency (CI) caused by severe forms of acute poisoning.
The study enrolled 60 patients (38 males, 22 females; mean age of the males 34.7 +/- 2.6 years, of the females - 28.4 +/- 3.2 years)admitted to the intensive care unit of St. Petersburg city center for treatment of acute poisoning for acute CI as a result of severe acute poisoning with neurotropic substances. The patients were divided into 2 groups matched by age, gender and severity of poisoning: group 1 (n = 32) received reamberin and standard treatment; group 2 (n = 28) received standard treatment alone.
The addition of reamberin to intensive treatment of acute CI alleviated severity of CI, enhanced recovery of functional activity of the brain, significantly reduced tissue hypoxia. All these positive effects improved clinical course of acute CI as shown by a shorter stay in the state of coma (reduction from 55 +/- 2.2 to 33 +/- 2.6 hours, shorter stay in the intensive care unit (reduction from 69.1 +/- 3.6 to 53.4 +/- 4.3 hours), reduced cost of the treatment.
In severe poisoning with neurotropic substances reamberin enhances correction of CI and increases tissue oxygen utilization.
研究底物抗缺氧药物雷美替胺对严重急性中毒所致脑功能不全（CI）患者的疗效。
本研究纳入60例患者（男性38例，女性22例；男性平均年龄34.7±2.6岁，女性平均年龄28.4±3.2岁），这些患者因神经毒性物质严重急性中毒导致急性CI，入住圣彼得堡市中心重症监护病房接受急性中毒治疗。将患者按年龄、性别和中毒严重程度分为两组：第1组（n = 32）接受雷美替胺和标准治疗；第2组（n = 28）仅接受标准治疗。
在急性CI强化治疗中加用雷美替胺可减轻CI严重程度，促进脑功能活动恢复，显著减轻组织缺氧。所有这些积极作用改善了急性CI的临床病程，表现为昏迷状态持续时间缩短（从55±2.2小时降至33±2.6小时），重症监护病房停留时间缩短（从69.1±3.6小时降至53.4±4.3小时），治疗费用降低。
在神经毒性物质严重中毒时，雷美替胺可增强对CI的纠正并提高组织氧利用率。
