Bech-Thomsen N, Poulsen T, Christensen F G, Lundgren K, Wulf H C
Department of Dermatology, Copenhagen University Hospital, Denmark.
Arch Dermatol Res. 1992;284(6):353-7. doi: 10.1007/BF00372039.
The carcinogenic effect of three UVA tanning sources was studied in lightly pigmented hairless mice. The three tanning sources (Bellarium-S SA-1-12, Philips TL 09R and Philips TL 10R) have different emission spectra, and emit different amounts of UVB. Radiation from the tanning sources was administered for 20 min/day, 5 day/week in daily doses equivalent to those used in suntan salons. The radiation was given alone or after 12 weeks of exposure to solar-simulated UV radiation (SOLAR UV) (10 min/day, 4 day/week; daily dose, 19.5 kJ/m2 UVA and 3.9 kJ/m2 UVB). Irradiation with Bellarium-S SA-1-12 for 47 weeks and Philips TL 09R for 74 weeks induced skin tumours in 20/20 and 13/20 of the animals, respectively. When irradiation with Bellarium-S SA-1-12 and PHilips TL 09R was administered after 12 weeks of SOLAR-UV exposure, a strong enhancement of SOLAR-UV-induced photocarcinogenesis was observed (p < 0.001). Irradiation with Philips TL 10R was only slightly carcinogenic, and during 85 weeks of irradiation only one skin tumor appeared in a group of 20 mice. However, when irradiation with Philips TL 10R was administered after 12 weeks of exposure to SOLAR UV, an enhancement of SOLAR-UV-induced carcinogenesis was observed (p < 0.001). Our results suggest that the hazards of exposure to commercial tanning devices are increased when they are used after a period of natural sun exposure. Even tanning sources with a low carcinogenic potential are able to increase SOLAR-UV-induced carcinogenesis significantly.
在浅色无毛小鼠中研究了三种UVA晒黑光源的致癌作用。这三种晒黑光源（Bellarium-S SA-1-12、飞利浦TL 09R和飞利浦TL 10R）具有不同的发射光谱，且发射不同量的UVB。以相当于日光浴沙龙使用的每日剂量，每天照射晒黑光源20分钟，每周照射5天。单独给予辐射，或在暴露于模拟太阳紫外线（SOLAR UV）12周后给予辐射（每天10分钟，每周4天；每日剂量，19.5 kJ/m2 UVA和3.9 kJ/m2 UVB）。用Bellarium-S SA-1-12照射47周和用飞利浦TL 09R照射74周分别在20只动物中的20只和13只中诱发了皮肤肿瘤。当在SOLAR-UV暴露12周后给予Bellarium-S SA-1-12和飞利浦TL 09R照射时，观察到SOLAR-UV诱导的光致癌作用有强烈增强（p<0.001）。用飞利浦TL 10R照射仅具有轻微致癌性，在85周的照射期间，一组20只小鼠中仅出现了一个皮肤肿瘤。然而，当在暴露于SOLAR UV 12周后给予飞利浦TL 10R照射时，观察到SOLAR-UV诱导的致癌作用增强（p<0.001）。我们的结果表明，在经过一段时间的自然阳光照射后使用商业晒黑设备，暴露的危害会增加。即使是致癌潜力低的晒黑光源也能够显著增加SOLAR-UV诱导的致癌作用。
