Warzecha Heribert, Mason Hugh S
Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, New York 14850, USA.
J Plant Physiol. 2003 Jul;160(7):755-64. doi: 10.1078/0176-1617-01125.
Phytopharming, the production of protein biologicals in recombinant plant systems, has shown great promise in studies performed over the past 13 years. A secretory antibody purified from transgenic tobacco was tested successfully in humans, and prevented bacterial re-colonization after topical application in the mouth. Rapid production of patient-tailored anti-lymphoma antibodies in recombinant Tobamovirus-infected tobacco may provide effective cancer therapy. Many different candidate vaccines from bacterial and viral sources have been expressed in transgenic plants, and three human clinical trials with oral delivery of transgenic plant tissues have shown exciting results. The use of crop plants with agricultural practice could allow cheap production of valuable proteins, while providing enhanced safety by avoidance of animal viruses or other contaminants. However development of this technology must carefully consider the means to ensure the separation of food and medicinal products when crop plants are used for phytopharming.
植物制药，即在重组植物系统中生产蛋白质生物制品，在过去13年的研究中已显示出巨大的前景。从转基因烟草中纯化的一种分泌性抗体在人体中进行了成功测试，并在口腔局部应用后防止了细菌再次定植。在重组烟草花叶病毒感染的烟草中快速生产针对患者定制的抗淋巴瘤抗体可能会提供有效的癌症治疗方法。许多来自细菌和病毒源的不同候选疫苗已在转基因植物中表达，三项关于口服转基因植物组织的人体临床试验已显示出令人振奋的结果。将农作物用于农业生产可以廉价地生产有价值的蛋白质，同时通过避免动物病毒或其他污染物来提高安全性。然而，当将农作物用于植物制药时，这项技术的发展必须仔细考虑确保食品和药品分离的方法。
