Porwollik Steffen, McClelland Michael
Sidney Kimmel Cancer Center, 10835 Altman Row, San Diego, CA 92121, USA.
Microbes Infect. 2003 Sep;5(11):977-89. doi: 10.1016/s1286-4579(03)00186-2.
Comparative genomics and microarrays reveal that the genomes of different Salmonella enterica serovars are distinguished from each other by the presence or absence of hundreds of genes. The distribution of these variable genome regions is often not clonal. Therefore, lateral gene transfer (LGT) plays an important role in diversity among Salmonella. Overall, almost one quarter of the entire S. enterica sv Typhimurium genome may have been introduced by LGT.
比较基因组学和微阵列分析表明,不同肠炎沙门氏菌血清型的基因组因数百个基因的有无而相互区分。这些可变基因组区域的分布通常不是克隆性的。因此,横向基因转移(LGT)在沙门氏菌的多样性中起着重要作用。总体而言,鼠伤寒沙门氏菌整个基因组中近四分之一可能是通过横向基因转移引入的。