Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.
Nat Commun. 2021 Mar 25;12(1):1862. doi: 10.1038/s41467-021-22198-w.
Replication inside macrophages is crucial for systemic dissemination of in hosts. In a article, Jiang et al. show that stimulates glycolysis and represses serine synthesis in macrophages, leading to accumulation of host glycolytic intermediates that the bacteria use as carbon source and as cues for its replication.
在宿主中，巨噬细胞内的复制对于的全身传播至关重要。在一篇文章中，Jiang 等人表明，刺激巨噬细胞中的糖酵解并抑制丝氨酸合成，导致宿主糖酵解中间产物的积累，细菌将这些中间产物用作碳源，并将其作为自身复制的线索。
