Guard Jean
U. S. Department of Agriculture, Agricultural Research Service, U. S. National Poultry Research Center, 950 College Station Road, Athens, GA 30605, USA.
Pathogens. 2022 May 14;11(5):581. doi: 10.3390/pathogens11050581.
This review revisits previous concepts on biological phenomenon contributing to the success of the subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines.
本综述重新审视了之前关于促成亚种I作为病原体成功的生物学现象的概念，并对其进行扩展，纳入了基于全基因组测序（WGS）的流行病学进展。讨论不仅限于WGS在流行病学中的应用，还考虑了作为生物体生物学特征的表型如何与其基因型相关联，以形成对相互作用组的认识。解读基因组与蛋白质的相互作用、代谢通量的影响、表观遗传修饰及其他复杂生化过程，将带来新的治疗方法、控制措施、环境修复手段，以及改进的疫苗设计。
