de Vries André H M, Mulders Jan M C A, Mommers John H M, Henderickx Huub J W, de Vries Johannes G
DSM Pharma Chemicals-Advanced Synthesis, Catalysis & Development, P.O. Box 18, 6160 MD Geleen, The Netherlands.
Org Lett. 2003 Sep 4;5(18):3285-8. doi: 10.1021/ol035184b.
[reaction: see text] Ligand-free Pd(OAc)(2) can be used as a catalyst in the Heck reaction of aryl bromides as long as the amount of catalyst is kept between 0.01 and 0.1 mol %. At higher concentrations palladium black forms and the reaction stops. The actual catalyst is monomeric. Palladacycles merely serve as a source of ligand-free palladium in Heck reactions of aryl bromides.
[反应：见正文] 只要催化剂的用量保持在0.01至0.1摩尔%之间，无配体的醋酸钯（Pd(OAc)₂）就可用于芳基溴的Heck反应。在较高浓度下会形成钯黑，反应停止。实际的催化剂是单体。在芳基溴的Heck反应中，钯环仅作为无配体钯的来源。
