Harrison R F
RCSI Department of Obstetrics & Gynaecology, Rotunda Hospital, Dublin, Ireland.
Eur J Obstet Gynecol Reprod Biol. 1992 Dec 28;47(3):175-9. doi: 10.1016/0028-2243(92)90147-q.
An international ten-centre double-blind trial comparing hCG with placebo in the management of habitual abortion was conducted. The dose regime for hCG used was 10,000 IU i.m. on first diagnosis of pregnancy, 5000 IU thence twice weekly to week 12, followed by once weekly up to week 16. Identical ampoulage of placebo was used. Seventy-five patients completed the trial. Thirty-six received hCG and thirty-nine placebo. 83% of the pregnancies on hCG were successful compared with 79% on placebo (P = 0.45). Of the 25 defined as having no cause for their habitual abortion history, 83% on hCG were successful, as were 85% on placebo (P = 0.73). No significant differences were found between the two therapies in terms of delivery weight, placental weight or neonatal Apgar score. This study fails to confirm previous promising placebo-controlled data advocating the use of hCG in habitual abortion.
开展了一项国际多中心双盲试验，比较人绒毛膜促性腺激素（hCG）与安慰剂对习惯性流产的治疗效果。hCG的用药方案为：妊娠首次诊断时肌肉注射10000国际单位，之后每周两次，每次5000国际单位，直至第12周，随后每周一次，直至第16周。安慰剂使用相同规格的安瓿。75名患者完成了试验。36名接受hCG治疗，39名接受安慰剂治疗。接受hCG治疗的妊娠成功率为83%，而接受安慰剂治疗的为79%（P = 0.45）。在25名被确定无习惯性流产病史病因的患者中，接受hCG治疗的成功率为83%，接受安慰剂治疗的为85%（P = 0.73）。两种治疗方法在分娩体重、胎盘重量或新生儿阿氏评分方面均未发现显著差异。这项研究未能证实之前有前景的安慰剂对照数据所主张的hCG用于习惯性流产的效果。
