Harrison R F
Royal College of Surgeons, Dublin, Ireland.
Int J Fertil Menopausal Stud. 1993 May-Jun;38(3):160-5.
To compare the effect of hCG therapy with placebo or bed rest in women with threatened abortion.
Random assignment, double-blind.
Community hospitals.
Sixty-one women with viable pregnancies under 8 weeks' gestation on admission to hospital were randomly allocated to receive injections of hCG or placebo, or were advised to rest in bed.
Abortion vs. continuation of pregnancy at 16 weeks' gestation.
Thirty-one aborted: 6/20 on hCG, 10/21 on placebo, 15/20 on bed rest. hCG vs. bed rest, P < .01; placebo vs. bed rest, hCG vs. placebo--not significant. Plasma progesterone: continuing pregnancy > abortion, P < .01; continued with hCG vs. aborted on placebo, P < .001; continued with hCG vs. aborted with bed rest, P < .001. No significant differences in pregnancy/birth complications or infants' birth weight. Female/male ratio was 2:1.
hCG is significantly better than bed rest.
比较人绒毛膜促性腺激素（hCG）治疗与安慰剂或卧床休息对先兆流产女性的疗效。
随机分组，双盲。
社区医院。
61名入院时妊娠8周以内且胚胎存活的女性被随机分配接受hCG注射、安慰剂注射或被建议卧床休息。
妊娠16周时流产与继续妊娠情况。
31例流产：接受hCG治疗的20例中有6例，接受安慰剂治疗的21例中有10例，卧床休息的20例中有15例。hCG治疗组与卧床休息组比较，P < 0.01；安慰剂治疗组与卧床休息组比较、hCG治疗组与安慰剂治疗组比较，差异无统计学意义。血浆孕酮水平：继续妊娠者高于流产者，P < 0.01；接受hCG治疗后继续妊娠者与接受安慰剂治疗后流产者比较，P < 0.001；接受hCG治疗后继续妊娠者与卧床休息后流产者比较，P < 0.001。妊娠/分娩并发症及婴儿出生体重方面无显著差异。男女比例为2:1。
hCG治疗明显优于卧床休息。
