Owens O J, Leake R E
Department of Biochemistry, Glasgow University, UK.
Eur J Obstet Gynecol Reprod Biol. 1992 Dec 28;47(3):223-8. doi: 10.1016/0028-2243(92)90155-r.
Epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) content was measured in normal ovaries and benign ovarian tumours. Epidermal growth factor was present in 12.7% of normal ovaries, with a range 0.030-0.533 ng/mg DNA, and in 31.8% of benign ovarian tumours, with a range 0.1335-2.080 ng/ml DNA. TGF alpha was present in 84.5% of normal ovaries, with a range of values from 0.037-18.2 ng/mg DNA, and in 84.1% of benign ovarian tumours, with a range of 0.083-195 ng/mg DNA. The TGF alpha content in post menopausal benign ovarian tumours was significantly higher (P < 0.0001) than TGF alpha in the pre-menopausal normal ovarian group. The frequency of detection and levels of TGF alpha measured were significantly higher than those of EGF in the normal ovary group (P < 0.001) and also in the benign ovarian group (P < 0.005). We conclude that TGF alpha is the predominant growth factor present in normal ovaries and benign ovarian tumours.
在正常卵巢组织和良性卵巢肿瘤中测量了表皮生长因子（EGF）和转化生长因子α（TGFα）的含量。表皮生长因子在12.7%的正常卵巢组织中存在，DNA含量范围为0.030 - 0.533 ng/mg，在31.8%的良性卵巢肿瘤中存在，DNA含量范围为0.1335 - 2.080 ng/ml。转化生长因子α在84.5%的正常卵巢组织中存在，DNA含量范围为0.037 - 18.2 ng/mg，在84.1%的良性卵巢肿瘤中存在，DNA含量范围为0.083 - 195 ng/mg。绝经后良性卵巢肿瘤中的转化生长因子α含量显著高于绝经前正常卵巢组（P < 0.0001）。在正常卵巢组（P < 0.001）和良性卵巢组（P < 0.005）中，转化生长因子α的检测频率和测量水平均显著高于表皮生长因子。我们得出结论，转化生长因子α是正常卵巢组织和良性卵巢肿瘤中存在的主要生长因子。
