Owens O J, Leake R E
Department of Biochemistry, Glasgow University, UK.
Eur J Obstet Gynecol Reprod Biol. 1992 Dec 28;47(3):229-33. doi: 10.1016/0028-2243(92)90156-s.
Epidermal growth factor receptor (EGFR) was assayed in 52 women who had normal ovaries removed at hysterectomy and in 30 women with benign ovarian tumours. The histology of each ovary was recorded. A single point screen was performed on all samples and in positive cases a full Scatchard analysis. EGFR was present in 8 of 52 normal ovaries (15.4%) and 3 contained the high-affinity component while 5 had the low affinity component. In the benign ovarian tumour group 4 of 30 tumours (13.3%) had receptor present, one was high affinity and 3 were low affinity in type. We can conclude that EGFR is detectable only at low frequency in normal and benign ovarian tumours.
对52例子宫切除术中切除的正常卵巢的女性和30例患有良性卵巢肿瘤的女性进行了表皮生长因子受体（EGFR）检测。记录了每个卵巢的组织学情况。对所有样本进行了单点筛选，阳性病例进行了完整的Scatchard分析。52个正常卵巢中有8个（15.4%）存在EGFR，其中3个含有高亲和力成分，5个含有低亲和力成分。在良性卵巢肿瘤组中，30个肿瘤中有4个（13.3%）存在受体，其中1个为高亲和力类型，3个为低亲和力类型。我们可以得出结论，在正常和良性卵巢肿瘤中，EGFR仅在低频率下可检测到。
