自闭症谱系障碍儿童的血液单核细胞计数和新蝶呤水平较高。
High blood monocyte counts and neopterin levels in children with autistic disorder.
作者信息
Sweeten Thayne L, Posey David J, McDougle Christopher J
机构信息
Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 46202-4800, USA.
出版信息
Am J Psychiatry. 2003 Sep;160(9):1691-3. doi: 10.1176/appi.ajp.160.9.1691.
OBJECTIVE
Leukocyte counts and plasma neopterin levels were determined in autistic children and matched healthy comparison subjects.
METHOD
Blood from 31 autistic children and 28 age- and gender-matched healthy comparison subjects was analyzed for numbers of neutrophils, eosinophils, basophils, lymphocytes, monocytes, and total leukocytes and for plasma neopterin levels.
RESULTS
The monocyte count and neopterin level were significantly higher in the autistic children than in the comparison subjects.
CONCLUSIONS
These results suggest that the immune system may be activated in some children with autism.
目的
测定自闭症儿童及相匹配的健康对照受试者的白细胞计数和血浆新蝶呤水平。
方法
分析31名自闭症儿童和28名年龄及性别相匹配的健康对照受试者的血液，以检测中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、淋巴细胞、单核细胞和总白细胞数量以及血浆新蝶呤水平。
结果
自闭症儿童的单核细胞计数和新蝶呤水平显著高于对照受试者。
结论
这些结果表明，部分自闭症儿童的免疫系统可能被激活。
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