注意力缺陷多动障碍不一致的同卵双胞胎的大脑解剖学异常。
Anatomic brain abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder.
作者信息
Castellanos F Xavier, Sharp Wendy S, Gottesman Rebecca F, Greenstein Deanna K, Giedd Jay N, Rapoport Judith L
机构信息
Child Psychiatry Branch, National Institute of Mental Health/NIH, Bethesda, MD, USA.
出版信息
Am J Psychiatry. 2003 Sep;160(9):1693-6. doi: 10.1176/appi.ajp.160.9.1693.
OBJECTIVE
To examine brain-behavior relationships in attention deficit hyperactivity disorder (ADHD), the authors obtained magnetic resonance imaging (MRI) scans of monozygotic twins discordant for ADHD.
METHOD
National recruitment was followed by in-person assessment. MRI scans were measured algorithmically for nine pairs of monozygotic twins discordant for ADHD.
RESULTS
The affected twins had significantly smaller caudate volumes (mean difference=-0.56 ml, CI=-0.92 to -0.21) than their unaffected co-twins.
CONCLUSIONS
These results provide further support for striatal models of ADHD pathophysiology.
目的
为研究注意力缺陷多动障碍（ADHD）中的脑-行为关系，作者对患ADHD的同卵双胞胎进行了磁共振成像（MRI）扫描。
方法
在全国范围内招募受试者，随后进行现场评估。对9对患ADHD的同卵双胞胎进行了MRI扫描的算法测量。
结果
患病双胞胎的尾状核体积明显小于未患病的同卵双胞胎（平均差异=-0.56毫升，可信区间=-0.92至-0.21）。
结论
这些结果为ADHD病理生理学的纹状体模型提供了进一步支持。
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