Seth Late R K, Kharb Simmi, Kharb D P
Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, Haryana.
Indian J Med Sci. 2003 Aug;57(8):350-4.
Despite the extensive research for many years throughout the world, the etiopathogenesis of cancer still remains obscure. For the early detection of carcinoma of various origins, a number of biochemical markers have been studied to evaluate the malignancy.
To analyse serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) in carcinoma breast patients.
SETTINGS & DESIGN: The serum biochemical markers were estimated in twenty five histopathologically confirmed patients with carcinoma breast and equal number of healthy age- matched individuals served as control.
MATERIAL & METHODS: Serum gamma glutamyl transpeptidase (GGTP), lactate dehydrogenase (LDH) and superoxide dismutase (SOD) were estimated and their sensitivity determined.
Data was analysed with student's 't'-test and sensitivity score of these markers was determined.
RESULTS & CONCLUSIONS: The mean serum GGTP, LDH and SOD activities in patients with carcinoma breast were tremendously increased as compared to controls, and a steady increase was observed in their activities from stage I through stage IV as well as following distant metastasis. Serum GGTP, LDH and SOD might prove to be most sensitive biomarkers in carcinoma breast in early detection of the disease.
尽管世界各地多年来进行了广泛研究，但癌症的病因发病机制仍不清楚。为了早期检测各种起源的癌症，人们研究了许多生化标志物来评估恶性程度。
分析乳腺癌患者血清γ-谷氨酰转肽酶（GGTP）、乳酸脱氢酶（LDH）和超氧化物歧化酶（SOD）。
对25例经组织病理学确诊的乳腺癌患者以及同等数量年龄匹配的健康个体进行血清生化标志物检测，后者作为对照。
检测血清γ-谷氨酰转肽酶（GGTP）、乳酸脱氢酶（LDH）和超氧化物歧化酶（SOD），并确定其敏感性。
采用学生t检验分析数据，并确定这些标志物的敏感性评分。
与对照组相比，乳腺癌患者血清GGTP、LDH和SOD活性显著升高，从I期到IV期以及远处转移后其活性呈稳步上升。血清GGTP、LDH和SOD可能是乳腺癌早期检测中最敏感的生物标志物。
