Choudhari Archana, Desai Prakash, Indumati V, Kadi Sumangala
Department of Biochemistry, Mahadevappa Rampure Medical College, Gulbarga, Karnataka, India.
Indian J Med Sci. 2013 May-Jun;67(5-6):123-9.
To assess the clinical utility of Serum adenosine deaminase, gamma glutamyl transferase and alkaline phosphatase in carcinoma breast patients for diagnostic and prognostic purpose.
Thirty clinically and histopathologically confirmed female patients of the age group of 30-65 years served as cases and 30 normal healthy females in the same age group served as controls. The parameters were estimated by standard biochemical methods.
The activities of serum ADA, GGT and ALP were significantly increased in carcinoma breast patients when compared to controls. When all the 4 stages of carcinoma breast were compared with controls ADA and GGT were increased significantly. Whereas ALP showed a significant increase only in stage II, III and IV. Interstage comparison yielded a steady and progressive increase in the activities of these enzymes from stage I-IV.
The study concludes that enzyme markers like serum ADA and GGT could be sensitive, specific and cost effective biomarkers for diagnosing carcinoma breast and for monitoring its progression. Serum ALP level can be used as important biomarker for detecting metastasis and for differentiation of carcinoma breast with and without metastasis.
评估血清腺苷脱氨酶、γ-谷氨酰转移酶和碱性磷酸酶在乳腺癌患者中用于诊断和预后目的的临床效用。
选取30例年龄在30 - 65岁之间、经临床和组织病理学确诊的女性乳腺癌患者作为病例组，另选30例同年龄组的正常健康女性作为对照组。采用标准生化方法测定各项参数。
与对照组相比，乳腺癌患者血清ADA、GGT和ALP的活性显著升高。将乳腺癌的所有4个阶段与对照组进行比较时，ADA和GGT显著升高。而ALP仅在II期、III期和IV期显著升高。各阶段之间的比较显示，从I期到IV期，这些酶的活性呈稳定且逐渐升高的趋势。
该研究得出结论，血清ADA和GGT等酶标志物可能是用于诊断乳腺癌及其进展监测的敏感、特异且具有成本效益的生物标志物。血清ALP水平可作为检测转移以及鉴别有无转移的乳腺癌的重要生物标志物。
