Kułak Wojciech, Sobaniec Wojciech
Klinika Neurologii Dzieciecej Akademii Medycznej, 15-274 Białystok, ul. Waszyngtona 17.
Przegl Lek. 2003;60 Suppl 1:23-7.
Cerebral palsy (CP) occurs in 1.4-3.0 per 1000 live births children. Major clinical features of CP are: spasticity of extremities, extrapyramidale movements, dyskinesis and ataxia. Spastic diplegia is the most common type of CP. Spectral analysis and coherence EEG are noninvasive measures of the functional relationship between brain regions and are evaluated to determine electrophysiologic abnormalities of neurologic and psychiatric disorders. The objective of this study was to estimate EEG spectral power density and coherence in children with spastic diplegia. A group of 29 children (15 girls and 14 boys) with DS recruited from the Department and Clinic of the Pediatric Neurology Ward in Medical Academy in Białystok, were studied. Their ages ranged from 6-14 years, mean 8.79 +/- 3.23 years. EEG results were compared with a control group of 31 healthy children with normal EEG records. For every subject, 20 artifact-free EEG epochs, each 2 s duration were selected for spectral analysis and coherence functions. A standard (fast fourier transformation) algorithm of signal processing was used. Significant decrease of power alpha at occipital derivations demonstrated in children with DS. On the other hand, there was an increase of theta power and delta bands almost in all leads. An increase of beta power was no significant compared with controls. Significant decrease of interhemispheric coherence values in children with DS for the alpha and theta band frequencies and in a few cases decrease of delta and beta bands were observed. Differences of intrahemispheric coherence values were detected at central-temporal and temporal-occipital leads. The presented results support anatomic-neurophysiologic abnormalities demonstrated in children with DS.
脑瘫（CP）在每1000例活产儿童中的发生率为1.4 - 3.0例。CP的主要临床特征为：肢体痉挛、锥体外系运动、运动障碍和共济失调。痉挛性双侧瘫是CP最常见的类型。频谱分析和脑电图相干性是脑区之间功能关系的非侵入性测量方法，用于评估神经和精神疾病的电生理异常。本研究的目的是评估痉挛性双侧瘫患儿的脑电图频谱功率密度和相干性。对从比亚韦斯托克医学院儿科神经病房招募的29名患有痉挛性双侧瘫的儿童（15名女孩和14名男孩）进行了研究。他们的年龄在6至14岁之间，平均为8.79 +/- 3.23岁。将脑电图结果与31名脑电图记录正常的健康儿童对照组进行比较。对于每个受试者，选择20个无伪迹的脑电图时段，每个时段持续2秒，用于频谱分析和相干函数分析。使用了标准的（快速傅里叶变换）信号处理算法。患有痉挛性双侧瘫的儿童枕部导联的α功率显著降低。另一方面，几乎所有导联的θ功率和δ波段均增加。与对照组相比，β功率增加不显著。观察到患有痉挛性双侧瘫的儿童在α和θ频段频率的半球间相干值显著降低，在少数情况下，δ和β波段也降低。在中央 - 颞部和颞 - 枕部导联检测到半球内相干值的差异。所呈现的结果支持了患有痉挛性双侧瘫的儿童存在解剖 - 神经生理异常。
