Leyssen Pieter, Croes Romaric, Rau Philipp, Heiland Sabine, Verbeken Erik, Sciot Raphael, Paeshuyse Jan, Charlier Nathalie, De Clercq Erik, Meyding-Lamadé Uta, Neyts Johan
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
Brain Pathol. 2003 Jul;13(3):279-90. doi: 10.1111/j.1750-3639.2003.tb00028.x.
Infection of hamsters with the murine flavivirus Modoc results in (meningo)encephalitis, which is, during the acute phase, frequently associated with flaccid paralysis, as also observed in patients with West Nile virus encephalitis. Twenty percent of the hamsters that recover from the acute encephalitis develop life-long neurological sequelae, reminiscent of those observed, for example, in survivors of Japanese encephalitis. Magnetic resonance imaging and histology revealed severe lesions predominantly located in the olfactory-limbic system, both in hamsters with acute encephalitis as in survivors. Prominent pathology was also detected in the spinal cord of hamsters with paralysis. Modoc virus infections in hamsters provide a unique model for the study of encephalitis, a poliomyelitis-like syndrome and neurological sequelae following flavivirus infection.
用鼠源黄病毒莫多克感染仓鼠会导致（脑膜）脑炎，在急性期，这常与弛缓性麻痹相关，西尼罗河病毒脑炎患者也有此现象。从急性脑炎中康复的仓鼠有20%会出现终身神经后遗症，这让人联想到在日本脑炎幸存者中观察到的后遗症。磁共振成像和组织学显示，无论是患有急性脑炎的仓鼠还是幸存者，严重病变主要位于嗅脑边缘系统。在瘫痪仓鼠的脊髓中也检测到明显病变。仓鼠感染莫多克病毒为研究黄病毒感染后的脑炎、脊髓灰质炎样综合征和神经后遗症提供了一个独特模型。
