黄病毒感染仓鼠模型中的急性脑炎、脊髓灰质炎样综合征及神经后遗症
Acute encephalitis, a poliomyelitis-like syndrome and neurological sequelae in a hamster model for flavivirus infections.
作者信息
Leyssen Pieter, Croes Romaric, Rau Philipp, Heiland Sabine, Verbeken Erik, Sciot Raphael, Paeshuyse Jan, Charlier Nathalie, De Clercq Erik, Meyding-Lamadé Uta, Neyts Johan
机构信息
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
出版信息
Brain Pathol. 2003 Jul;13(3):279-90. doi: 10.1111/j.1750-3639.2003.tb00028.x.
Abstract
Infection of hamsters with the murine flavivirus Modoc results in (meningo)encephalitis, which is, during the acute phase, frequently associated with flaccid paralysis, as also observed in patients with West Nile virus encephalitis. Twenty percent of the hamsters that recover from the acute encephalitis develop life-long neurological sequelae, reminiscent of those observed, for example, in survivors of Japanese encephalitis. Magnetic resonance imaging and histology revealed severe lesions predominantly located in the olfactory-limbic system, both in hamsters with acute encephalitis as in survivors. Prominent pathology was also detected in the spinal cord of hamsters with paralysis. Modoc virus infections in hamsters provide a unique model for the study of encephalitis, a poliomyelitis-like syndrome and neurological sequelae following flavivirus infection.
摘要
用鼠源黄病毒莫多克感染仓鼠会导致（脑膜）脑炎，在急性期，这常与弛缓性麻痹相关，西尼罗河病毒脑炎患者也有此现象。从急性脑炎中康复的仓鼠有20%会出现终身神经后遗症，这让人联想到在日本脑炎幸存者中观察到的后遗症。磁共振成像和组织学显示，无论是患有急性脑炎的仓鼠还是幸存者，严重病变主要位于嗅脑边缘系统。在瘫痪仓鼠的脊髓中也检测到明显病变。仓鼠感染莫多克病毒为研究黄病毒感染后的脑炎、脊髓灰质炎样综合征和神经后遗症提供了一个独特模型。
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本文引用的文献
1
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Can Med Assoc J. 1960 Feb 13;82(7):355-8.
2
Neurologic sequelae of Japanese B encephalitis.日本乙型脑炎的神经后遗症
Neurology. 1961 Jul;11:553-9. doi: 10.1212/wnl.11.7.553.
3
Neuropathology of experimental West Nile virus infection in monkeys.猴子实验性西尼罗河病毒感染的神经病理学
J Neuropathol Exp Neurol. 1956 Oct;15(4):448-60. doi: 10.1097/00005072-195610000-00007.
4
Poliomyelitis due to West Nile virus.西尼罗河病毒引起的脊髓灰质炎
N Engl J Med. 2002 Oct 17;347(16):1280-1. doi: 10.1056/NEJM200210173471616. Epub 2002 Sep 23.
5
A poliomyelitis-like syndrome from West Nile virus infection.西尼罗河病毒感染所致的类脊髓灰质炎综合征
N Engl J Med. 2002 Oct 17;347(16):1279-80. doi: 10.1056/NEJM2002c021587. Epub 2002 Sep 23.
6
Acute viral encephalitis: the recent progress.急性病毒性脑炎：近期进展
Intern Med. 2002 Jun;41(6):420-8. doi: 10.2169/internalmedicine.41.420.
7
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Emerg Infect Dis. 2002 Mar;8(3):245-51. doi: 10.3201/eid0803.010238.
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9
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MMWR Morb Mortal Wkly Rep. 2001 Sep 7;50(35):761-4.
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Emerg Infect Dis. 2001 Jul-Aug;7(4):714-21. doi: 10.3201/eid0704.010420.
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