Nelson D L, Frazier D E, Ericson J E, Tarr M J, Mathes L E
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210.
Immunopharmacol Immunotoxicol. 1992;14(4):925-38. doi: 10.3109/08923979209009242.
The in vivo effects of perfluorodecanoic acid (PFDA) exposure on antibody production, delayed type hypersensitivity (DTH), and natural killer (NK) cell activity were determined. Fischer 344 rats were injected with PFDA (20 mg/kg or 50 mg/kg, 8 days or 30 days prior to sacrifice) and were immunized with keyhole limpet hemocyanin (KLH). Pair-fed and ad libitum-fed control rats were included to evaluate effects of PFDA-induced anorexia. KLH-specific IgG2a production was significantly decreased (p < 0.05) in PFDA-treated rats when compared to ad libitum-fed and pair-fed controls at 8 days but not at 30 days following PFDA treatment. The DTH response of PFDA-treated rats was decreased 8 days and 30 days after PFDA treatment when compared to ad libitum-fed and pair-fed controls, however, the decrease was not statistically significant. NK activity 30 days after PFDA treatment was significantly elevated (p < 0.05) when compared to ad libitum-fed controls, but pair-fed controls had similarly elevated NK activity. NK activity at 8 days after PFDA treatment was not significantly altered. In conclusion, PFDA has been demonstrated to have immunomodulatory effects, some of which may be associated with drug-induced anorexia.
研究了全氟癸酸（PFDA）暴露对抗体产生、迟发型超敏反应（DTH）和自然杀伤（NK）细胞活性的体内影响。给Fischer 344大鼠注射PFDA（20毫克/千克或50毫克/千克，在处死前8天或30天），并用钥孔戚血蓝蛋白（KLH）进行免疫。设置配对喂养和自由进食的对照大鼠以评估PFDA诱导的厌食症的影响。与自由进食和配对喂养的对照相比，PFDA处理的大鼠在PFDA处理后8天而非30天时，KLH特异性IgG2a的产生显著降低（p<0.05）。与自由进食和配对喂养的对照相比，PFDA处理的大鼠在PFDA处理后8天和30天时DTH反应降低，然而，这种降低没有统计学意义。与自由进食的对照相比，PFDA处理后30天NK活性显著升高（p<0.05），但配对喂养的对照具有相似升高的NK活性。PFDA处理后8天NK活性没有显著改变。总之，已证明PFDA具有免疫调节作用，其中一些可能与药物诱导的厌食症有关。
