Van Rafelghem M J, Noren C W, Menahan L A, Peterson R E
School of Pharmacy, University of Wisconsin, Madison 53706.
Toxicol Lett. 1988 Jan;40(1):57-69. doi: 10.1016/0378-4274(88)90183-x.
Energy metabolism and body composition were investigated in perfluorodecanoic acid (PFDA)-treated rats (single i.p. dose of 20, 40 or 80 mg/kg) and their respective pair-fed counterparts 7 days after dosing. Cumulative feed intake and body weight were decreased in a dose-dependent manner. However, PFDA-treated rats either gained less weight or lost more weight (dependent on the dose administered) than their pair-fed, vehicle-treated counterparts, even though feed intake in these two treatment groups was similar. Energy expenditure, determined indirectly by quantifying oxygen consumption and carbon dioxide production, decreased in a dose-dependent fashion, yet it was similar in PFDA-treated rats and their pair-fed counterparts at a given dose. Body composition analysis indicated a dose-dependent decrease in carcass water and protein content in both PFDA-treated rats and pair-fed partners, while total amount of ash remained unchanged in all treatment groups. These alterations in body composition are compatible with a negative energy balance. Even though PFDA-treated rats had a lower body weight than their pair-fed counterparts at each dose level, they were found to have a greater carcass fat content. Thus, at maintenance (i.e., zero change of body weight) PFDA-treated rats require a higher caloric intake associated with a greater body fat content than vehicle-treated animals.
在给大鼠腹腔注射单剂量20、40或80mg/kg全氟癸酸（PFDA）7天后，对其能量代谢和身体组成进行了研究，并与其各自的配对喂食对照大鼠进行比较。累积采食量和体重呈剂量依赖性下降。然而，尽管这两个治疗组的采食量相似，但与配对喂食、接受赋形剂处理的对照大鼠相比，PFDA处理的大鼠体重增加较少或体重减轻较多（取决于给药剂量）。通过量化氧气消耗和二氧化碳产生间接测定的能量消耗呈剂量依赖性下降，但在给定剂量下，PFDA处理的大鼠及其配对喂食对照大鼠的能量消耗相似。身体组成分析表明，PFDA处理的大鼠及其配对喂食对照大鼠的胴体水分和蛋白质含量均呈剂量依赖性下降，而所有治疗组的灰分总量保持不变。身体组成的这些变化与负能量平衡一致。尽管在每个剂量水平下，PFDA处理的大鼠体重均低于其配对喂食对照大鼠，但发现它们的胴体脂肪含量更高。因此，在维持状态下（即体重无变化），与接受赋形剂处理的动物相比，PFDA处理的大鼠需要更高的热量摄入，且体脂含量更高。
