Leigh J P, Fries J F, Parikh N
Department of Medicine, Stanford University School of Medicine, CA.
J Rheumatol. 1992 Dec;19(12):1906-11.
A longitudinal sample of patients with rheumatoid arthritis (RA) from Santa Clara County, CA was analyzed. Severity was measured with the Disability Index from the Health Assessment Questionnaire (HAQ). First, 6 cohorts were created of women and men with 0 to 10, > 10 to 20, and > 20 years of duration of illness in 1981. Experiences of the 6 cohorts were studied from 1981 to 1989. For both sexes, and both samples which alternately included and excluded the deceased, persons with > 20 years of duration experienced faster deterioration than those with < 20 years. Second, multiple regression models were estimated which treated the Disability Index as the dependent variable. In the regression models, the Disability Index worsened more quickly for women than men, for persons with few rather than many years of education, and for older than younger persons. Regression models which excluded an intercept term suggested a unique "S" shaped curve that described the Disability Index and duration relation.
对来自加利福尼亚州圣克拉拉县的类风湿性关节炎（RA）患者纵向样本进行了分析。采用健康评估问卷（HAQ）的残疾指数来衡量疾病严重程度。首先，在1981年，根据患病时长将患者分为6组，每组包含男性和女性，患病时长分别为0至10年、大于10至20年以及大于20年。对这6组人群在1981年至1989年期间的情况进行了研究。对于男性和女性，以及在交替纳入和排除死亡病例的两个样本中，患病时长大于20年的患者比患病时长小于20年的患者病情恶化得更快。其次，估计了多个以残疾指数为因变量的回归模型。在回归模型中，女性、受教育年限少的人以及年长者的残疾指数恶化速度比男性、受教育年限多的人以及年轻者更快。排除截距项的回归模型显示出一条独特的“S”形曲线，描述了残疾指数与患病时长的关系。
