Dragoi George, Harris Kenneth D, Buzsáki György
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA.
Neuron. 2003 Aug 28;39(5):843-53. doi: 10.1016/s0896-6273(03)00465-3.
In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP) of intrinsic hippocampal pathways abolished existing place fields, created new place fields, and rearranged the temporal relationship within the affected population. The effect of LTP on neuron discharge was rate and context dependent. The LTP-induced "remapping" occurred without affecting the global firing rate of the network. The findings support the view that learned place representation can be accomplished by LTP-like synaptic plasticity within intrahippocampal networks.
在大脑中，信息由神经元集群的放电模式以及单个神经元之间突触连接的强度进行编码。我们在此报告，通过改变海马体网络内的突触权重，“位置”细胞对环境的表征会发生改变。海马体固有通路的长时程增强（LTP）消除了现有的位置野，产生了新的位置野，并重新排列了受影响群体内的时间关系。LTP对神经元放电的影响取决于速率和环境。LTP诱导的“重映射”在不影响网络整体放电率的情况下发生。这些发现支持了这样一种观点，即习得的位置表征可以通过海马体内网络中类似LTP的突触可塑性来实现。
