• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在人类空间导航过程中对海马-内嗅皮层复合体的非侵入性调节。

Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans.

机构信息

Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.

Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), Clinique Romande de Réadaptation, École Polytechnique Fédérale de Lausanne (EPFL Valais), Sion, Switzerland.

出版信息

Sci Adv. 2024 Nov;10(44):eado4103. doi: 10.1126/sciadv.ado4103. Epub 2024 Oct 30.

DOI:10.1126/sciadv.ado4103
PMID:39475597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11524170/
Abstract

Because of the depth of the hippocampal-entorhinal complex (HC-EC) in the brain, understanding of its role in spatial navigation via neuromodulation was limited in humans. Here, we aimed to better elucidate this relationship in healthy volunteers, using transcranial temporal interference electric stimulation (tTIS), a noninvasive technique allowing to selectively neuromodulate deep brain structures. We applied tTIS to the right HC-EC in either continuous or intermittent theta-burst stimulation patterns (cTBS or iTBS), compared to a control condition, during a virtual reality-based spatial navigation task and concomitant functional magnetic resonance imaging. iTBS improved spatial navigation performance, correlated with hippocampal activity modulation, and decreased grid cell-like activity in EC. Collectively, these data provide the evidence that human HC-EC activity can be directly and noninvasively modulated leading to changes of spatial navigation behavior. These findings suggest promising perspectives for patients suffering from cognitive impairment such as following traumatic brain injury or dementia.

摘要

由于大脑中海马-内嗅皮层复合体（HC-EC）的深度，通过神经调制理解其在空间导航中的作用在人类中受到限制。在这里，我们旨在使用经颅时间干扰电刺激（tTIS）更好地阐明健康志愿者中的这种关系，这是一种非侵入性技术，可选择性地调节深部脑结构。我们在虚拟现实空间导航任务和伴随的功能磁共振成像期间，将 tTIS 应用于右侧 HC-EC 的连续或间歇 theta 爆发刺激模式（cTBS 或 iTBS），与对照条件进行比较。iTBS 改善了空间导航性能，与海马活动调制相关，并降低了 EC 中的网格细胞样活动。总的来说，这些数据提供了证据，证明人类 HC-EC 活动可以直接和非侵入性地调节，从而导致空间导航行为的变化。这些发现为遭受认知障碍（例如创伤性脑损伤或痴呆）的患者提供了有前途的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/878035499688/sciadv.ado4103-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/f4284d298744/sciadv.ado4103-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/3161961e9a2c/sciadv.ado4103-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/df35e9abb9a9/sciadv.ado4103-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/885a3244d443/sciadv.ado4103-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/962e26705425/sciadv.ado4103-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/878035499688/sciadv.ado4103-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/f4284d298744/sciadv.ado4103-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/3161961e9a2c/sciadv.ado4103-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/df35e9abb9a9/sciadv.ado4103-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/885a3244d443/sciadv.ado4103-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/962e26705425/sciadv.ado4103-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0466/11524170/878035499688/sciadv.ado4103-f6.jpg

相似文献

1
Noninvasive modulation of the hippocampal-entorhinal complex during spatial navigation in humans.在人类空间导航过程中对海马-内嗅皮层复合体的非侵入性调节。
Sci Adv. 2024 Nov;10(44):eado4103. doi: 10.1126/sciadv.ado4103. Epub 2024 Oct 30.
2
Functional connectivity changes in the entorhinal cortex of taxi drivers.出租车司机内嗅皮层功能连接变化。
Brain Behav. 2018 Sep;8(9):e01022. doi: 10.1002/brb3.1022. Epub 2018 Aug 15.
3
Hexadirectional Modulation of Theta Power in Human Entorhinal Cortex during Spatial Navigation.人类内嗅皮层在空间导航过程中theta 功率的六向调制。
Curr Biol. 2018 Oct 22;28(20):3310-3315.e4. doi: 10.1016/j.cub.2018.08.029. Epub 2018 Oct 11.
4
Can we study 3D grid codes non-invasively in the human brain? Methodological considerations and fMRI findings.我们能否在人脑内无创性地研究 3D 栅格码？方法学考虑和 fMRI 研究结果。
Neuroimage. 2019 Feb 1;186:667-678. doi: 10.1016/j.neuroimage.2018.11.041. Epub 2018 Nov 24.
5
The functional role of human right hippocampal/parahippocampal theta rhythm in environmental encoding during virtual spatial navigation.人类右侧海马体/海马旁回θ节律在虚拟空间导航过程中环境编码中的功能作用。
Hum Brain Mapp. 2017 Mar;38(3):1347-1361. doi: 10.1002/hbm.23458. Epub 2016 Nov 4.
6
Environmental Barriers Disrupt Grid-like Representations in Humans during Navigation.环境障碍会干扰人类在导航过程中的网格状表现。
Curr Biol. 2019 Aug 19;29(16):2718-2722.e3. doi: 10.1016/j.cub.2019.06.072. Epub 2019 Aug 1.
7
Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior.人类海马体的重映射和重新定位预测了上下文相关的空间行为。
Nat Neurosci. 2021 Jun;24(6):863-872. doi: 10.1038/s41593-021-00835-3. Epub 2021 Apr 15.
8
Distance and Direction Codes Underlie Navigation of a Novel Semantic Space in the Human Brain.距离和方向代码为人类大脑中新型语义空间的导航提供基础。
J Neurosci. 2020 Mar 25;40(13):2727-2736. doi: 10.1523/JNEUROSCI.1849-19.2020. Epub 2020 Feb 14.
9
Increased Hippocampal Excitability and Altered Learning Dynamics Mediate Cognitive Mapping Deficits in Human Aging.海马兴奋性增加和学习动态改变介导人类衰老认知映射缺陷。
J Neurosci. 2021 Apr 7;41(14):3204-3221. doi: 10.1523/JNEUROSCI.0528-20.2021. Epub 2021 Mar 1.
10
Mapping of a non-spatial dimension by the hippocampal-entorhinal circuit.海马体-内嗅皮层回路对非空间维度的映射。
Nature. 2017 Mar 29;543(7647):719-722. doi: 10.1038/nature21692.

引用本文的文献

1
Design of TI-TMS system for deep brain stimulation with higher focus in neural modulation.用于深度脑刺激且在神经调制方面具有更高聚焦度的经颅感应磁刺激（TI-TMS）系统设计。
Sci Rep. 2025 Jul 1;15(1):20757. doi: 10.1038/s41598-025-08598-8.
2
Human Applications of Transcranial Temporal Interference Stimulation: A Systematic Review.经颅颞叶干扰刺激在人体中的应用：一项系统综述。
medRxiv. 2025 May 22:2025.05.16.25327804. doi: 10.1101/2025.05.16.25327804.
3
Novel Strategies for Cognitive Enhancement via Noninvasive Neuromodulation.通过非侵入性神经调节实现认知增强的新策略。

本文引用的文献

1
Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills.非侵入性刺激人类纹状体可破坏运动技能的强化学习。
Nat Hum Behav. 2024 Aug;8(8):1581-1598. doi: 10.1038/s41562-024-01901-z. Epub 2024 May 29.
2
Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions.非侵入性深部经颅颞刺激的安全性、耐受性和盲法效率：250 多次治疗的初步经验。
J Neural Eng. 2024 Mar 11;21(2). doi: 10.1088/1741-2552/ad2d32.
3
Non-invasive temporal interference electrical stimulation of the human hippocampus.
Neurosci Bull. 2025 Apr 21. doi: 10.1007/s12264-025-01394-4.
无创性颞叶内电刺激人类海马区。
Nat Neurosci. 2023 Nov;26(11):1994-2004. doi: 10.1038/s41593-023-01456-8. Epub 2023 Oct 19.
4
Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning.经颅直流电刺激增强运动技能学习：来自人类初级运动皮层的证据
Nat Neurosci. 2023 Nov;26(11):2005-2016. doi: 10.1038/s41593-023-01457-7. Epub 2023 Oct 19.
5
Promising neurostimulation routes for targeting the hippocampus to improve episodic memory: A review.有前景的靶向海马体的神经刺激途径以改善情景记忆：综述。
Brain Res. 2023 Sep 15;1815:148457. doi: 10.1016/j.brainres.2023.148457. Epub 2023 Jun 12.
6
Successful wayfinding in age: A scoping review on spatial navigation training in healthy older adults.老年人成功的寻路：关于健康老年人空间导航训练的范围综述
Front Psychol. 2022 Aug 16;13:867987. doi: 10.3389/fpsyg.2022.867987. eCollection 2022.
7
Dissecting motor skill acquisition: Spatial coordinates take precedence.剖析运动技能习得：空间坐标占主导地位。
Sci Adv. 2022 Jul 22;8(29):eabo3505. doi: 10.1126/sciadv.abo3505. Epub 2022 Jul 20.
8
Medial and orbital frontal cortex in decision-making and flexible behavior.决策和灵活行为中的额中回和眶额皮层。
Neuron. 2022 Sep 7;110(17):2743-2770. doi: 10.1016/j.neuron.2022.05.022. Epub 2022 Jun 14.
9
Spatial navigation in older adults with mild cognitive impairment and dementia: A systematic review and meta-analysis.老年人轻度认知障碍和痴呆症的空间导航：系统评价和荟萃分析。
Exp Gerontol. 2022 Aug;165:111852. doi: 10.1016/j.exger.2022.111852. Epub 2022 May 27.
10
Sense of self impacts spatial navigation and hexadirectional coding in human entorhinal cortex.自我意识影响人类内嗅皮层的空间导航和六向编码。
Commun Biol. 2022 May 2;5(1):406. doi: 10.1038/s42003-022-03361-5.