Zee-Cheng R K
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City.
Methods Find Exp Clin Pharmacol. 1992 Nov;14(9):725-36.
Shi-Quan-Da-Bu-Tang (Ten Significant Tonic Decoction), or SQT (Juzentaihoto, TJ-48) was formulated by Taiping Hui-Min Ju (Public Welfare Pharmacy Bureau) in Chinese Song Dynasty in AD 1200. It is prepared by extracting a mixture of ten medical herbs (Rehmannia glutinosa, Paeonia lactiflora, Liqusticum wallichii, Angelica sinesis, Glycyrrhiza uralensis, Poria cocos, Atractylodes macrocephala, Panax ginseng. Astragalus membranaceus and Cinnamomum cassia) that tone the blood and vital energy, and strengthen health and immunity. This potent and popular prescription has traditionally been used against anemia, anorexia, extreme exhaustion, fatigue, kidney and spleen insufficiency and general weakness, particularly after illness. In order to restore immunity in cancer patients, potentiate the therapeutic effect and ameliorate adverse toxicity of anticancer agents, 116 Chinese herbal formularies (Kampo) have been screened and evaluated. Fifteen compounds were found to have such actions. Among these, SQT was selected as the most effective as a potent biological response modifier. During the last eight years, animal models and clinical studies have revealed that SQT demonstrates extremely low toxicity (LD50 > 15 g/kg op murine), self-regulatory and synergistic actions of its components in immunomodulatory and immunopotentiating effects (by stimulating hemopoietic factors and interleukins production in association with NK cells, etc.), potentiates therapeutic activity in chemotherapy (mitomycin, cisplatin, cyclophosphamide and fluorouracil) and radiotherapy, inhibits the recurrence of malignancies, prolongs survival, as well as ameliorate and/or prevents adverse toxicities (GI disturbances such as anorexia, nausea, vomiting, hematotoxicity, immunosuppression, leukopenia, thrombocytopenia, anemia and nephropathy, etc.) of many anticancer drugs. The application and mechanistic studies of SQT in future development have potential importance in basic and clinical research of the traditional Chinese therapeutic approach of "toning the blood and strengthening Qi (vital energy)" in cancer immunotherapy.
十全大补汤由公元1200年中国宋朝的太平惠民局（公益药房）研制而成。它是通过提取十种草药（熟地黄、白芍、川芎、当归、甘草、茯苓、白术、人参、黄芪和肉桂）的混合物制成的，这些草药能补血益气，增强体质和免疫力。这种强效且常用的方剂传统上用于治疗贫血、厌食、极度疲惫、疲劳、脾肾虚弱和全身虚弱，尤其是病后。为了恢复癌症患者的免疫力、增强抗癌药物的治疗效果并改善其不良反应，对116种中药方剂（汉方）进行了筛选和评估。发现有15种化合物具有此类作用。其中，十全大补汤被选为最有效的强效生物反应调节剂。在过去八年中，动物模型和临床研究表明，十全大补汤毒性极低（小鼠半数致死量>15g/kg），其成分在免疫调节和免疫增强作用方面具有自我调节和协同作用（通过刺激造血因子和白细胞介素与自然杀伤细胞等联合产生），增强化疗（丝裂霉素、顺铂、环磷酰胺和氟尿嘧啶）和放疗的治疗活性，抑制恶性肿瘤复发，延长生存期，以及改善和/或预防许多抗癌药物的不良反应（胃肠道紊乱如厌食、恶心、呕吐、血液毒性、免疫抑制、白细胞减少、血小板减少、贫血和肾病等）。十全大补汤在未来发展中的应用和机制研究在“补血益气”中医治疗方法在癌症免疫治疗的基础和临床研究中具有潜在重要性。
