Krishtal Oleg
Bogomoletz Institute of Physiology, Bogomoletz Str. 4, 01024, Kiev, Ukraine.
Trends Neurosci. 2003 Sep;26(9):477-83. doi: 10.1016/S0166-2236(03)00210-8.
Acid-sensing ionic channels (ASICs) are almost ubiquitous in the mammalian nervous system, both at the periphery and in the brain. Strong evidence for the physiological function of these molecules has come from recent knockout experiments. Now it is clear that ASICs are important for certain sensory modalities (mechanoreception and nociception) at the periphery and for learning and memory in the brain. The actual mechanisms by which the acid-gated channels serve these functions remain unclear. The question of whether tissue pH is subject to quick fluctuations of a magnitude sufficient to activate ASICs is a crucial point that will determine the functional significance of these channels.
酸敏感离子通道（ASICs）在哺乳动物神经系统中几乎无处不在，无论是在外周还是在大脑中。这些分子生理功能的有力证据来自最近的基因敲除实验。现在很清楚，ASICs在外周的某些感觉模态（机械感受和伤害感受）以及大脑的学习和记忆方面都很重要。酸门控通道发挥这些功能的实际机制仍不清楚。组织pH值是否会出现足以激活ASICs的快速大幅波动这一问题，是决定这些通道功能重要性的关键要点。
