Calautti Cinzia, Leroy Francois, Guincestre Jean-Yves, Baron Jean-Claude
Department of Neurology, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Neuroimage. 2003 Aug;19(4):1650-4. doi: 10.1016/s1053-8119(03)00205-2.
Five patients with left striatocapsular infarction were studied twice with PET during auditory-cued right thumb-index tapping, around 2 months after stroke and again around 8 months after stroke. At PET1 and PET2, the ipsilesional primary sensorimotor (SM1) activation peak Talairach coordinates were compared to those from seven aged-matched healthy controls. At PET1, there was a significant posterior displacement of SM1 activation peak, which confirms a previous report and may represent unmasking/disinhibition of motor representations. Over time, there was no significant change in the coordinates, and no significant correlation between coordinate changes from PET1 to PET2 and concomitant motor recovery. The implications of posterior displacement of SM1 activation peak for recovery therefore remain elusive.
对5例左侧纹状体-囊梗死患者在听觉提示下进行右手拇指-示指轻敲动作时，分别于卒中后约2个月和卒中后约8个月进行了两次正电子发射断层扫描（PET）研究。在PET1和PET2时，将患侧初级感觉运动区（SM1）激活峰值的Talairach坐标与7名年龄匹配的健康对照者的坐标进行比较。在PET1时，SM1激活峰值有明显的向后移位，这证实了之前的一份报告，可能代表运动表征的去掩蔽/去抑制。随着时间的推移，坐标没有显著变化，从PET1到PET2的坐标变化与同时出现的运动恢复之间也没有显著相关性。因此，SM1激活峰值向后移位对恢复的影响仍然不明确。
