Katsanos Christos S, Grandjean Peter W, Moffatt Robert J
Metabolism Unit, Shriners Burns Hospital, 815 Market St., Galveston, TX 77550, USA.
J Appl Physiol (1985). 2004 Jan;96(1):181-8. doi: 10.1152/japplphysiol.00243.2003. Epub 2003 Aug 29.
This study was designed to assess differences in the intensity of exercise to attenuate postprandial lipemia (PPL). Thirteen healthy men (age 23.8 +/- 0.9 yr) participated in three random-ordered trials: in low-(25% peak oxygen consumption; Low) and moderate-intensity (65% peak oxygen consumption; Mod) exercise trials, which were completed 1 h before a high-fat meal (1.3 g fat/kg body mass), and a control (Con), fat meal only, trial. Venous blood samples were obtained before the fat meal, and at 2, 4, 6, 8, and 20 h after the fat meal. PPL in the Mod trial (267 +/- 50 mg.dl-1.8 h) was lower compared with that in either Con (439 +/- 81 mg.dl-1.8 h) or Low (403 +/- 91 mg.dl-1.8 h) trials (P < 0.05), whereas there was no difference in PPL between Con and Low trials (P > 0.05). High-density lipoprotein cholesterol (HDL-C) and HDL subtype 2 cholesterol were not different between or within trials (P > 0.05). Postprandial insulinemia was lower in the Mod trial (20.5 +/- 5.7 microIU.ml-1.8 h; P < 0.05), but not in the Low trial (31.4 +/- 4.7 microIU.ml-1.8 h), compared with that in the Con trial (34.9 +/- 5.0 microIU.ml-1.8 h). Postheparin lipoprotein lipase activity at 8 h was higher in the Low trial compared with that in either Con or Mod trials, whereas there were no differences between trials at 20 h. These results suggest that, when exercise is performed 1 h before a fat meal, only exercise of moderate but not of low intensity attenuates PPL and that this effect is not associated with changes in postheparin lipoprotein lipase activity.
本研究旨在评估不同强度运动对减轻餐后血脂异常（PPL）的作用。13名健康男性（年龄23.8±0.9岁）参与了三项随机顺序试验：在高脂餐（1.3 g脂肪/千克体重）前1小时完成的低强度（25%峰值耗氧量；低强度组）和中等强度（65%峰值耗氧量；中等强度组）运动试验，以及仅进食脂肪餐的对照（对照组）试验。在脂肪餐前以及脂肪餐后2、4、6、8和20小时采集静脉血样。中等强度组试验中的PPL（267±50 mg·dl⁻¹·8小时）低于对照组（439±81 mg·dl⁻¹·8小时）或低强度组（403±91 mg·dl⁻¹·8小时）试验（P<0.05），而对照组和低强度组试验之间的PPL无差异（P>0.05）。高密度脂蛋白胆固醇（HDL-C）和HDL 2亚型胆固醇在试验之间或试验内均无差异（P>0.05）。与对照组试验（34.9±5.0 μIU·ml⁻¹·8小时）相比，中等强度组试验中的餐后胰岛素血症较低（20.5±5.7 μIU·ml⁻¹·8小时；P<0.05），但低强度组试验中无此现象（31.4±4.7 μIU·ml⁻¹·8小时）。低强度组试验在8小时时的肝素后脂蛋白脂肪酶活性高于对照组或中等强度组试验，而在20小时时试验之间无差异。这些结果表明，当在脂肪餐前进食1小时进行运动时，只有中等强度而非低强度运动可减轻PPL，且这种作用与肝素后脂蛋白脂肪酶活性的变化无关。
