Fry M M, Vernau W, Pesavento P A, Brömel C, Moore P F
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Vet Pathol. 2003 Sep;40(5):556-62. doi: 10.1354/vp.40-5-556.
We describe a case of a dog with hepatosplenic lymphoma, a disease characterized by infiltration of the liver, spleen, and bone marrow with gammadelta T cells, absence of peripheral lymphadenopathy, and an aggressive clinical course. Physical examination findings, hematologic and biochemical abnormalities, and clinical course of the disease in this patient were similar to those in humans. Immunophenotyping of liver and spleen aspirates supported an antemortem diagnosis of T-cell lymphoma consistent with hepatosplenic lymphoma. The diagnosis was confirmed postmortem by a combination of routine histopathology, showing a consistent pattern of organ involvement, and immunohistochemistry showing the infiltrating neoplastic lymphocytes to be T cells expressing the gammadelta T-cell receptor. To our knowledge, this is the first reported case of hepatosplenic lymphoma in a dog.
我们描述了一例患有肝脾淋巴瘤的犬病例，该疾病的特征是肝脏、脾脏和骨髓被γδ T细胞浸润，无外周淋巴结病，且临床病程进展迅速。该患者的体格检查结果、血液学和生化异常以及疾病的临床病程与人类相似。肝脏和脾脏穿刺物的免疫表型分析支持生前诊断为与肝脾淋巴瘤一致的T细胞淋巴瘤。死后通过常规组织病理学（显示一致的器官受累模式）和免疫组织化学（显示浸润的肿瘤性淋巴细胞为表达γδ T细胞受体的T细胞）相结合的方法确诊。据我们所知，这是首例报道的犬肝脾淋巴瘤病例。
