Sisó S, Lorenzo V, Ferrer I, Villagrassa M, Pumarola M
Department of Animal Medicine and Surgery, Veterinary Faculty, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.
Vet Pathol. 2003 Sep;40(5):567-9. doi: 10.1354/vp.40-5-567.
A tumor located in the optic nerve extended through the optic chiasm, involving the hypophysis and the hypothalamic area in a 3.5-year-old male Boxer dog. It showed a biphasic pattern in which numerous highly fibrillated, well-differentiated pilocytic areas were intermingled with pleomorphic, microcystic tumor tissue. Immunohistochemical analysis of the tumor revealed that most of the neoplastic cells were immunoreactive for S-100 protein, with less intensity for glial fibrillary acidic protein (GFAP) and vimentin. A diagnosis of anaplastic astrocytoma was made on the basis of the histopathologic findings and immunohistochemical results. Moreover, there were similarities with the malignant variant of pilocytic astrocytoma described in human adults as an optic chiasmatic-hypothalamic glioma.
一只3.5岁的雄性拳师犬，视神经处的肿瘤延伸至视交叉，累及垂体和下丘脑区域。肿瘤呈双相模式，其中大量高度纤维化、分化良好的毛细胞型区域与多形性微囊性肿瘤组织相互交织。对肿瘤进行免疫组织化学分析发现，大多数肿瘤细胞对S-100蛋白呈免疫反应性，对胶质纤维酸性蛋白（GFAP）和波形蛋白的反应强度较低。根据组织病理学发现和免疫组织化学结果，诊断为间变性星形细胞瘤。此外，该肿瘤与人类成人中描述为视交叉-下丘脑胶质瘤的毛细胞型星形细胞瘤恶性变体存在相似之处。
