Department of Clinical Sciences, Bailey Small Animal Teaching Hospital, College of Veterinary Medicine, Auburn University, 1220 Wire Road, Auburn, Alabama 36830, USA (Charnock, Jukier, Moore); Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, Wisconsin 53706, USA (Shaw); Department of Pathology, College of Veterinary Medicine, Auburn University, 1130 Wire Road, Auburn, Alabama 36849, USA (Kramer, Brinker).
Can Vet J. 2023 Aug;64(8):727-732.
A 4-year-old mixed-breed dog was presented for hyphema and glaucoma of the right eye. Enucleation of the right globe was carried out, and histopathology examination revealed an optic nerve glioma with incomplete surgical margins. At 8 wk after surgery, the dog had depressed mentation and a diminished pupillary light reflex of the left eye. Magnetic resonance imaging revealed an irregular, heterogeneously T2 hyperintense/T1 isointense mass in the region of the optic chiasm. Compression of the rostral thalamus was present, with effacement of the pituitary gland and involvement of the right orbit. The dog was euthanized 4.5 mo after initial presentation. An undefined glioma of the right optic nerve with extension to the diencephalon was diagnosed on necropsy. Key clinical message: Although rare, intraocular glioma is a differential diagnosis for hyphema, glaucoma, and retinal detachment. Magnetic resonance imaging should be considered in cases of intraocular neoplasia, notably in those with incomplete surgical margins of the optic nerve.
一只 4 岁的杂种犬因右眼玻璃体积血和青光眼就诊。右眼行眼球摘除术，组织病理学检查显示视神经胶质瘤，且手术切缘不完整。术后 8 周，患犬出现精神沉郁和左眼瞳孔光反射减弱。磁共振成像显示视交叉区域存在形状不规则、T2 高信号/T1 等信号不均匀肿块。丘脑前部受压，垂体消失，右侧眼眶受累。患犬在初次就诊后 4.5 个月被安乐死。尸检诊断为右侧视神经胶质瘤，延伸至间脑，无法明确诊断。关键临床信息：尽管罕见，但眼内胶质瘤是玻璃体积血、青光眼和视网膜脱离的鉴别诊断之一。对于眼内肿瘤，特别是视神经手术切缘不完整的病例，应考虑进行磁共振成像检查。
