Quimby G F, Bonnice C A, Burstein S H, Eastwood G L
Ann Intern Med. 1986 May;104(5):616-9. doi: 10.7326/0003-4819-104-5-616.
To determine the effect of smoking on gastroduodenal mucosal prostaglandin synthesis, endoscopies were done after an overnight fast on 10 nonsmokers, 12 active smokers who smoked four cigarettes in the hour before endoscopy, and then 11 of the smokers who refrained from smoking for 12 hours. Biopsy samples of fundic, antral, and duodenal mucosae were incubated, and the accumulation of prostaglandin E2 and 6-keto-prostaglandin F1 alpha in the incubation medium was measured by radioimmunoassay. We assumed that accumulation of prostaglandins in the medium reflected mucosal synthesis. Comparison of active and inactive smoking showed that active smoking significantly depressed 6-keto-prostaglandin F1 alpha synthesis in antral and fundic mucosa and prostaglandin E2 synthesis in antral mucosa. Comparison of nonsmokers and inactive smokers showed no difference in prostaglandin synthesis. Active smoking causes a transient decrease in prostaglandin synthesis in fundic and antral mucosae. This depression of prostaglandin synthesis may help explain slower ulcer healing and predisposition to ulcer recurrence in smokers.
为确定吸烟对胃十二指肠黏膜前列腺素合成的影响，对10名不吸烟者、12名在胃镜检查前1小时吸4支烟的现吸烟者以及随后11名戒烟12小时的吸烟者进行了空腹过夜后的内镜检查。将胃底、胃窦和十二指肠黏膜的活检样本进行孵育，并用放射免疫分析法测定孵育培养基中前列腺素E2和6-酮-前列腺素F1α的积累量。我们假定培养基中前列腺素的积累反映了黏膜合成情况。现吸烟与戒烟后的比较显示，现吸烟显著降低了胃窦和胃底黏膜中6-酮-前列腺素F1α的合成以及胃窦黏膜中前列腺素E2的合成。不吸烟者与戒烟者的比较显示，前列腺素合成无差异。现吸烟导致胃底和胃窦黏膜中前列腺素合成短暂减少。前列腺素合成的这种抑制作用可能有助于解释吸烟者溃疡愈合较慢以及易复发溃疡的原因。
