非那西泮和氟硝西泮超低剂量的药理活性。
Pharmacological activity of phenazepam and flunitrazepam in ultralow doses.
作者信息
Molodavkin G M, Voronina T A, Chernyavskaya L I, Burlakova E B, Khorseva N I, Seredenin S B
机构信息
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2003 Jan;135 Suppl 7:39-41. doi: 10.1023/a:1024710225445.
PMID:12949644
Abstract
Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10(-9)-10(-15) mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of standard doses of tranquilizers.
摘要
对雄性远交白化大鼠进行的实验表明，苯二氮䓬类镇静剂非那西泮和氟硝西泮在超低剂量（10⁻⁹ - 10⁻¹⁵摩尔/千克）时，在冲突情境测试中产生抗焦虑作用。该作用并未伴随标准剂量镇静剂典型的肌松和镇静副作用。
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