人γ干扰素增强抗体的免疫otropic效应。（注：这里immunotropic可能是immunotrophic拼写有误，正常可能是免疫营养性等类似含义，具体准确意思需结合更详细文本确定）

Immunotropic effects of potentiated antibodies to human interferon-gamma.

作者信息

Sherstoboev E Yu, Masnaya N M, Churin A A, Borsuk O S, Martyushev A V, Sergeeva S A, Epstein O I, Dygai A M, Goldberg E D

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.

出版信息

Bull Exp Biol Med. 2003 Jan;135 Suppl 7:70-2. doi: 10.1023/a:1024734930896.

DOI:10.1023/a:1024734930896

PMID:12949656

Abstract

We studied immunotropic properties of antibodies to human interferon-gamma in homeopathic doses. The effects of these antibodies on the ratio between the counts of T helper (CD4+) and T suppressor cells (CD8+), production of interleukin-1 and interleukin-2, and functional activity of natural killer cells were evaluated. Potentiated antibodies slightly decreased the number of CD8+ cells in the spleen of experimental animals. After the addition to cultured human mononuclear cells the preparation produced a moderate comitogenic effect, stimulated proliferation of T and B lymphocytes, increased spontaneous and induced production of interleukin-1, and enhanced functional activity of natural killer cells (under certain conditions).

摘要

我们研究了顺势疗法剂量下抗人γ干扰素抗体的免疫调节特性。评估了这些抗体对辅助性T细胞（CD4+）与抑制性T细胞（CD8+）计数比例、白细胞介素-1和白细胞介素-2产生以及自然杀伤细胞功能活性的影响。增效抗体使实验动物脾脏中CD8+细胞数量略有减少。将该制剂添加到培养的人单核细胞中后，产生了适度的促有丝分裂作用，刺激T和B淋巴细胞增殖，增加白细胞介素-1的自发产生和诱导产生，并增强自然杀伤细胞的功能活性（在某些条件下）。