超低剂量的炎症介质抗体：缓激肽、组胺和血清素抗体的镇咳特性。

Ultralow doses of antibodies to inflammatory mediators: antitussive properties of antibodies to bradykinin, histamine, and serotonin.

作者信息

Epstein O I, Kovaleva V L, Zak M S, Dugina Yu L

机构信息

Materia Medica Holding Research-and-Production Company, Moscow.

出版信息

Bull Exp Biol Med. 2003 Jan;135 Suppl 7:146-9. doi: 10.1023/a:1024744627687.

DOI:10.1023/a:1024744627687

PMID:12949683

Abstract

We studied antitussive activity of antibodies to inflammatory mediators (bradykinin, histamine, and serotonin) in ultralow doses. Experiments were performed on guinea pigs with cough induced by citric acid and capsaicin. Test preparations suppressed cough produced by citric acid. Antibodies to bradykinin in ultralow doses were most potent in relieving capsaicin-induced cough (up to 85%); antibodies to serotonin and, particularly, to histamine produced a smaller effect. Potentiated histamine and serotonin possessed polymodal properties.

摘要

我们研究了超低剂量下针对炎症介质（缓激肽、组胺和血清素）的抗体的镇咳活性。实验在由柠檬酸和辣椒素诱发咳嗽的豚鼠身上进行。受试制剂抑制了柠檬酸引起的咳嗽。超低剂量下针对缓激肽的抗体在缓解辣椒素诱发的咳嗽方面最为有效（高达85%）；针对血清素尤其是组胺的抗体产生的效果较小。增强后的组胺和血清素具有多模态特性。