Kohler H, Bayry J, Nicoletti A, Kaveri S V
Department of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536, USA.
Scand J Immunol. 2003 Sep;58(3):285-9. doi: 10.1046/j.1365-3083.2003.01314.x.
Natural autoantibodies (NAbs), produced by B-1 B-cells, are directed against autoantigens and pathogens. NAbs can capture and present antigen to T helper cells thereby initiating adaptive immunities. It is proposed that screening for NAbs against pathogens will predict the strength of an antigen-induced immune response and could be used as a tool for vaccine development.
由B-1 B细胞产生的天然自身抗体（NAbs）可针对自身抗原和病原体。天然自身抗体能够捕获抗原并将其呈递给辅助性T细胞，从而启动适应性免疫。有人提出，筛选针对病原体的天然自身抗体将预测抗原诱导的免疫反应强度，并可作为疫苗开发的一种工具。
