Chissov V I, Sviridova I K, Sergeeva N S, Frank G A, Kirsanova V A, Achmedova S A, Reshetov I V, Filjushin M M, Barinov S M, Fadeeva I V, Komlev V S
P. A. Hertzen Moscow Oncological Institute, Rosmedtechnologies, Moscow, Russia.
Bull Exp Biol Med. 2008 Jul;146(1):139-43. doi: 10.1007/s10517-008-0222-3.
Biocompatibility of porous granulated bioceramic materials (hydroxyapatite, beta-tricalcium phosphate, hydroxyapatite-b-tricalcium phosphate complex (80:20 wt%), carbonate-containing hydroxyapatite, and silicon-containing hydroxyapatite) was shown in a subcutaneous test on BDF1 mice. Dynamic (up to 8 months) observation showed gradual replacement of the granular substance with de novo forming bone tissue with hemopoiesis foci on a model of fenestral defect in the shin bone in Wistar rats. By the rate of resorption, the materials rank as follows: silicon-containing hydroxyapatite<hydroxyapatite<hydroxyapatite-beta-tricalcium phosphate<beta-tricalcium phosphate<carbonate-containing hydroxyapatite. The rate of resorption in bone tissue defect was significantly higher than in the subcutaneous test, but lagged behind (even for tricalcium phosphate and carbonate-containing hydroxyapatite) bone tissue formation de novo.
在BDF1小鼠的皮下试验中显示了多孔粒状生物陶瓷材料（羟基磷灰石、β-磷酸三钙、羟基磷灰石-β-磷酸三钙复合物（80:20重量%）、含碳酸羟基磷灰石和含硅羟基磷灰石）的生物相容性。动态（长达8个月）观察表明，在Wistar大鼠胫骨开窗缺损模型中，颗粒物质逐渐被新生的骨组织替代，且有造血灶。就吸收速率而言，材料排序如下：含硅羟基磷灰石＜羟基磷灰石＜羟基磷灰石-β-磷酸三钙＜β-磷酸三钙＜含碳酸羟基磷灰石。骨组织缺损处的吸收速率明显高于皮下试验，但（即使对于磷酸三钙和含碳酸羟基磷灰石）仍落后于新生骨组织的形成。
