Yoshizumi M, Katoh I, Yoshida O, Kitagawa T, Nishimura T, Fukumura Y, Matsumoto T, Nishitani H
Department of Cardiovascular Surgery, University of Tokushima, Japan.
Tokushima J Exp Med. 1992 Dec;39(3-4):123-6.
A 58-year-old female patient with lymphedema of the left leg was treated by repeated intraarterial lymphocyte-injection therapy. To elucidate whether the injected lymphocytes act at the affected site of the leg, we examined the distribution of the In-111 oxine labeled lymphocytes injected into the proximal artery to the affected leg in comparison with the distribution in the other, healthy, leg. The radioactivity of the affected leg was almost two times higher than that of the healthy leg during the first 30 min after injection, and it remained higher even after 24 hours. The circumference of the affected leg of the patient decreased steadily during her hospital stay. These results, together with the clinical findings, suggest that some of the intraarterially-injected lymphocytes remained in the affected leg at least 24 hours and might play some role in reducing the volume of lymphedematous fluid.
一名58岁的左腿淋巴水肿女性患者接受了反复动脉内淋巴细胞注射治疗。为了阐明注入的淋巴细胞是否作用于腿部的患病部位，我们将注入患侧腿部近端动脉的铟-111氧嗪标记淋巴细胞的分布与另一侧健康腿部的分布进行了比较。注射后的前30分钟内，患侧腿部的放射性几乎是健康腿部的两倍，甚至在24小时后仍保持较高水平。患者住院期间，患侧腿部的周长稳步减小。这些结果与临床发现一起表明，动脉内注射的一些淋巴细胞至少在患侧腿部停留了24小时，可能在减少淋巴水肿液体积方面发挥了一定作用。
