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动脉内注射淋巴细胞治疗淋巴水肿。

Intraarterial lymphocytes injection for treatment of lymphedema.

作者信息

Katoh I, Harada K, Tsuda Y, Fujishima N, Egawa Y, Sugama M, Inoue K

出版信息

Jpn J Surg. 1984 Jul;14(4):331-4. doi: 10.1007/BF02469651.

DOI:10.1007/BF02469651
PMID:6492508
Abstract

We noted a marked improvement of lymphedema in a patient with recurrence of cancer 3 years after amputatio recti and with post-thrombotic syndrome of the leg, as the result of injection of a suspension of lymphocytes administrated as therapy against advanced cancer. Subsequently lymphocytes-injections were given 39 times to 7 patients with lymphedema of one limb, of various causes. A suspension of lymphocytes was injected repeatedly into the proximal artery of the affected limb. In one patient, lymphocytes were injected 4 times at intervals of 1 or 3 weeks. In most cases, this injection resulted in a marked reduction in the swelling of the affected limb and improvement was seen for several weeks or months. In all cases, there was a marked, continuous softening of the tissue.

摘要

我们注意到,一名患者在直肠截肢术后3年癌症复发且伴有腿部血栓后综合征,在注射淋巴细胞悬液作为晚期癌症治疗手段后,其淋巴水肿有显著改善。随后,对7例因各种原因导致单肢淋巴水肿的患者进行了39次淋巴细胞注射。将淋巴细胞悬液反复注射到患肢的近端动脉。在1例患者中,每隔1周或3周注射淋巴细胞4次。在大多数情况下,这种注射导致患肢肿胀明显减轻,且数周或数月内症状有所改善。在所有病例中,组织均有明显的持续软化。

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1
Intraarterial lymphocytes injection for treatment of lymphedema.动脉内注射淋巴细胞治疗淋巴水肿。
Jpn J Surg. 1984 Jul;14(4):331-4. doi: 10.1007/BF02469651.
2
Intraarterial lymphocyte-injection therapy for lymphedema of the leg: an examination using indium-111 oxine labeled autologous lymphocytes.动脉内注射淋巴细胞治疗腿部淋巴水肿:使用铟-111奥克辛标记的自体淋巴细胞进行的一项研究。
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[Lymphocyte injection for the treatment of lymphedema].[淋巴细胞注射治疗淋巴水肿]
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引用本文的文献

1
Use of Autologous Blood Components in Lymphedema Treatment: A Systematic Review.自体血液成分在淋巴水肿治疗中的应用:一项系统综述。
Cureus. 2019 Sep 12;11(9):e5638. doi: 10.7759/cureus.5638.

本文引用的文献

1
On the pathomechanism of development of postsurgical lymphedema.
Lymphology. 1973 Mar;6(1):35-51.