Dargenio R, Corbucci M G, Lamanna M A, Garcea N
Department of Obstetrics and Gynecology, Università Cattolica del Sarco Cuore, Rome, Italy.
Acta Eur Fertil. 1992 Mar-Apr;23(2):85-8.
Clinical and experimental evidence showed an increased concentration of prostaglandins in peritoneal fluid in cases of endometriosis. The aim of this study was to verify whether an antiprostaglandin drug can restore fertility in cases of endometriosis. For this reason endometriosis was induced in 4 groups of 10 rats. Group A was treated with indomethacin both in the pre-ovulatory and in the post-ovulatory phase. Group B was treated in the pre-ovulatory phase. Group C was treated in the post-ovulatory phase. Group D was not treated. Ten other rats (group E) underwent a sham operation and were used as a control. Twelve days after mating, gestational sacs and corpora lutea were counted and the nidation index was calculated. Only indomethacin administered during the pre-ovulatory phase completely restored fertility in these rats.
临床和实验证据表明，子宫内膜异位症患者腹腔液中前列腺素的浓度升高。本研究的目的是验证抗前列腺素药物是否能恢复子宫内膜异位症患者的生育能力。因此，对4组每组10只大鼠诱发子宫内膜异位症。A组在排卵前和排卵后阶段均用吲哚美辛治疗。B组在排卵前阶段治疗。C组在排卵后阶段治疗。D组未治疗。另外10只大鼠（E组）接受假手术并用作对照。交配12天后，计数妊娠囊和黄体，并计算着床指数。只有在排卵前阶段给予吲哚美辛才能使这些大鼠的生育能力完全恢复。
