Paniagua Estévez M, González Calleja I, González Lazo N, Jimenéz Mesa G, Hernández Miranda W
Instituto de Gastroenterología, La Habana, Cuba.
Acta Gastroenterol Latinoam. 1992;22(1):21-7.
Recent international publications remark the association about carcinoma of the colon and cholelithiasis. These two entities with similar geographical distribution can be seen frequently in the modern western societies, being the cause as aetiological factors the low content in dietetics fiber. Different studies about the carcinoma of the colon and cholelithiasis pathogenesis had lead the possibility that the abnormal degradation of bile acids for the colonic bacterias, could be responsible of each one of these illness. The exposition of colonic mucosa to products of degradation of bile acids, specially secondary bile acids, may play a role in the etiopathogenic of colon carcinoma. It was analysed 135 patients with colon carcinoma or adenomatosis polyps, 42 with cholelithiasis or cholecystectomized for the same cause (31.1%), although in the control group, only 2(5%) had cholelithiasis. The female predominated the group of colon carcinoma and cholelithiasis, as well as cholecystectomized for that cause. The most frequent associated pathology was the diverticulosis.
近期的国际出版物提及了结肠癌与胆石症之间的关联。在现代西方社会,这两种具有相似地理分布的疾病颇为常见,膳食纤维含量低被认为是其病因。关于结肠癌和胆石症发病机制的不同研究表明,结肠细菌对胆汁酸的异常降解可能是导致这两种疾病的原因。结肠黏膜暴露于胆汁酸降解产物,特别是次级胆汁酸,可能在结肠癌的发病过程中起作用。对135例结肠癌或息肉状腺瘤患者进行了分析,其中42例患有胆石症或因相同原因接受了胆囊切除术(31.1%),而在对照组中,只有2例(5%)患有胆石症。在结肠癌和胆石症患者组以及因该原因接受胆囊切除术的患者中,女性占主导。最常见的相关病理是憩室病。