Filipponi F, Bandettini L, Francini Naldi E, Filomena A
Chir Ital. 1985 Jun;37(3):300-4.
It results cholelithiasis is very frequently associated to colorectal cancer. Clinical and autoptic studies thereabout result to be doubtful. In the present research, the Authors evaluated the proliferative activity of colonic mucous membrane, through the mitotic index, and the secretion of mucins, with histochemical methods, in control subjects and cholelithiasic patients. The results show no significant differences in both groups; the data obtained are discussed in the light of the importance of the biologic parameter considered in the evaluation of risk groups for colorectal neoplasms and, moreover, as morphologic support to the clinical question.
结果显示，胆结石与结直肠癌常常相关。关于这方面的临床和尸检研究结果存疑。在本研究中，作者通过有丝分裂指数评估结肠黏膜的增殖活性，并采用组织化学方法检测对照组和胆结石患者黏蛋白的分泌情况。结果表明两组之间无显著差异；根据在评估结直肠肿瘤风险组时所考虑的生物学参数的重要性，以及作为对临床问题的形态学支持，对所得数据进行了讨论。
