Yochem John, Herman Robert K
Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA.
Development. 2003 Oct;130(20):4761-8. doi: 10.1242/dev.00701.
The analysis of genetically mosaic worms, in which some cells carry a wild-type gene and others are homozygous mutant, can reveal where in the animal a gene acts to prevent the appearance of a mutant phenotype. In this primer article, we describe how Caenorhabditis elegans genetic mosaics are generated, identified and analyzed, and we discuss examples in which the analysis of mosaic worms has provided important information about the development of this organism.
对基因嵌合蠕虫的分析，其中一些细胞携带野生型基因而其他细胞是纯合突变体，可以揭示在动物体内基因在何处发挥作用以防止突变表型的出现。在这篇入门文章中，我们描述了秀丽隐杆线虫基因嵌合体是如何产生、鉴定和分析的，并且我们讨论了一些例子，其中对嵌合蠕虫的分析提供了有关这种生物体发育的重要信息。
