宿主对炭疽致死毒素的反应：意外发现。
The host response to anthrax lethal toxin: unexpected observations.
作者信息
Prince Alice S
机构信息
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
出版信息
J Clin Invest. 2003 Sep;112(5):656-8. doi: 10.1172/JCI19581.
Abstract
Bacillus anthracis, the causative agent of anthrax, is believed to induce disease and death in humans in an endotoxic shock-like manner. A comprehensive study of the effects of anthrax toxin in mice demonstrates that toxin-induced death is mediated not by cytokine release, as previously thought, but by hypoxia-induced liver failure. The study strongly suggests that the therapies developed for treatment of cytokine-mediated septic shock will not be appropriate for the treatment of anthrax.
摘要
炭疽杆菌是炭疽病的病原体，据信它以类似内毒素休克的方式在人类中引发疾病和死亡。一项关于炭疽毒素对小鼠影响的全面研究表明，毒素诱导的死亡并非如先前认为的那样由细胞因子释放介导，而是由缺氧诱导的肝衰竭介导。该研究强烈表明，为治疗细胞因子介导的脓毒症休克而开发的疗法不适用于炭疽病的治疗。
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本文引用的文献
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