Koh W H, Boey M L
Department of Rheumatology and Immunology, Tan Tock Seng Hospital, Singapore.
Ann Acad Med Singap. 1992 Nov;21(6):821-2.
A patient with rheumatoid arthritis developed rapid onset of peripheral neuropathy whilst on treatment with intra-muscular (IM) gold (Sodium Aurothiomalate). At the time of admission, the arthritis was relatively quiescent. Electromyogram showed evidence of sensorimotor polyneuropathy. Investigations excluded other causes of polyneuropathy. Sural nerve biopsy did not reveal inflammation or vasculitis. The patient's condition improved after cessation of gold therapy. Gold induced neuropathy should be considered in a patient with rheumatoid arthritis who presents with polyneuropathy while on gold therapy.
一名类风湿性关节炎患者在接受肌肉注射金制剂（硫代苹果酸金钠）治疗时，迅速出现了周围神经病变。入院时，关节炎相对静止。肌电图显示存在感觉运动性多神经病的证据。检查排除了多神经病的其他病因。腓肠神经活检未发现炎症或血管炎。停用金治疗后，患者病情有所改善。对于在接受金治疗时出现多神经病的类风湿性关节炎患者，应考虑金诱导的神经病变。
