金制剂治疗类风湿关节炎的比较毒性
Comparative toxicity of gold preparations in treatment of rheumatoid arthritis.
作者信息
Lawrence J S
出版信息
Ann Rheum Dis. 1976 Apr;35(2):171-3. doi: 10.1136/ard.35.2.171.
Patients with rheumatoid arthritis have been treated alternately with aurothioglucose and aurothiomalate. In the earlier part of the study an oily suspension of aurothioglucose and an aqueous solution of aurothiomalate were used, but later an aqueous solution of aurothioglucose was alternated with the oily suspension and an oily suspension of aurothiomalate with the aqueous solution. Skin eruptions, stomatitis, and albuminuria were significantly more common in patients treated with the aqueous solution than with the oily suspension.
类风湿性关节炎患者交替接受金硫葡萄糖和金硫苹果酸治疗。在研究前期，使用金硫葡萄糖的油性混悬液和金硫苹果酸的水溶液，但后来金硫葡萄糖水溶液与油性混悬液交替使用，金硫苹果酸油性混悬液与水溶液交替使用。与油性混悬液治疗的患者相比，接受水溶液治疗的患者出现皮疹、口腔炎和蛋白尿的情况明显更为常见。
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