Petrovic M, Eljarrat E, Lopez De Alda M J, Barceló D
Department of Environmental Chemistry, IIQAB-CSIC, c/ Jordi Girona 18-26, 08034 Barcelona, Spain.
Anal Bioanal Chem. 2004 Feb;378(3):549-62. doi: 10.1007/s00216-003-2184-7. Epub 2003 Sep 2.
An overview of Toxicity Identification and Evaluation (TIE) procedures, used for the effect-based analysis of endocrine disrupting compounds (EDCs) in environmental samples, is presented. Future trends in advanced chemical analysis of EDCs and some emerging contaminants are outlined. The review also gives an overview of concentration levels found in environmental samples and discusses the correlation of calculated estrogenicity (based on chemical analysis of target EDCs) with that measured by various bioassays.
本文介绍了毒性鉴定与评价(TIE)程序的概述,该程序用于对环境样品中的内分泌干扰化合物(EDC)进行基于效应的分析。概述了EDC和一些新兴污染物的先进化学分析的未来趋势。该综述还概述了在环境样品中发现的浓度水平,并讨论了(基于目标EDC的化学分析)计算得出的雌激素活性与通过各种生物测定法测得的雌激素活性之间的相关性。