舍曲林对强迫症患者手部运动的运动学方面的影响。
Effects of sertraline on kinematic aspects of hand movements in patients with obsessive-compulsive disorder.
作者信息
Mergl Roland, Mavrogiorgou Paraskevi, Juckel Georg, Zaudig Michael, Hegerl Ulrich
机构信息
Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig-Maximilians-Universität München, Nussbaumstrasse 7, 80336, München, Germany.
出版信息
Psychopharmacology (Berl). 2004 Jan;171(2):179-85. doi: 10.1007/s00213-003-1568-x. Epub 2003 Aug 30.
RATIONALE
Movement disorders such as disturbances of fine motor co-ordination are a frequent phenomenon in patients with obsessive-compulsive disorder (OCD).
OBJECTIVES
Our aim was to investigate changes of hand-motor dysfunction in OCD patients under the influence of 10-week treatment with sertraline and behaviour therapy.
METHODS
We examined the performance of 40 patients satisfying DSM-IV criteria for OCD before and under this therapy using a digitising tablet and kinematic analysis of handwriting and drawing movements. Forty healthy controls were also tested (test-retest interval: 10 weeks).
RESULTS
The speed of drawing was significantly lower in OCD patients than in controls (mean+/-standard deviation=197.03+/-113.26 mm/s for patients and 182.48+/-189.61 mm/s for controls; P=0.01). After 10 weeks of therapy, this parameter normalised in patients (from 197.03+/-113.26 mm/s to 163.66+/-101.92 mm/s; P=0.001).
CONCLUSIONS
Hand-motor dysfunction (especially bradykinesia) improves with a serotonin-enhancing therapy in OCD patients.
理论依据
运动障碍，如精细运动协调障碍，在强迫症（OCD）患者中是一种常见现象。
目的
我们的目的是研究在接受10周舍曲林治疗和行为疗法的影响下，强迫症患者手部运动功能障碍的变化。
方法
我们使用数位板以及对手写和绘图动作进行运动学分析，对40名符合DSM-IV强迫症标准的患者在治疗前和治疗期间进行了检查。还对40名健康对照者进行了测试（重测间隔：10周）。
结果
强迫症患者的绘图速度显著低于对照组（患者的平均值±标准差=197.03±113.26毫米/秒，对照组为182.48±189.61毫米/秒；P=0.01）。经过10周治疗后，该参数在患者中恢复正常（从197.03±113.26毫米/秒降至163.66±101.92毫米/秒；P=0.001）。
结论
强迫症患者的手部运动功能障碍（尤其是运动迟缓）通过血清素增强疗法得到改善。
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