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单次酒精硬化疗法治疗有症状的良性肝囊肿,酒精暴露时间为10分钟:初步结果

Single-session alcohol sclerotherapy in symptomatic benign hepatic cysts performed with a time of exposure to alcohol of 10 min: initial results.

作者信息

Larssen Trond B, Rosendahl Karen, Horn Arild, Jensen Dag K, Rørvik Jarle

机构信息

Department of Radiology, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway.

出版信息

Eur Radiol. 2003 Dec;13(12):2627-32. doi: 10.1007/s00330-003-1923-7. Epub 2003 Sep 3.

Abstract

The aim of this study was to evaluate the 1-year results of single-session sclerotherapy of symptomatic benign non-parasitic liver cysts performed with maximum 10 min time of ethanol exposure. During the period 1995-1999, 15 symptomatic liver cysts in nine patients--eight women and one man--were treated with 10 min time of exposure to ethanol. Ultrasound-guided puncture combined with fluoroscopy was used for catheter placement. Alcohol sclerotherapy was performed with a maximum volume of ethanol 96% of 10% of the cyst volume, never exceeding 100 ml. At follow-up the patients were examined with liver function tests, ultrasound or CT examination, clinical examination, and interview by a gastrointestinal surgeon. Ten cysts in seven patients (six women and one man; age range 44-61 years, median age 58 years), who had a follow-up of at least 1 year, were included. The original cyst volumes were 30-4110 ml (median 392 ml). After a follow-up period of 12-47 months (median 23 months), cyst volumes were 0-523 ml (median 21.5 ml) with a reduction of the median cyst volume by 95% ( p<0,005). All patients experienced relief of their clinical symptoms. Except for pain, no complications were observed. Sclerotherapy using only one session and maximum 10 min time of exposure to ethanol represents an effective treatment of symptomatic liver cysts.

摘要

本研究的目的是评估单次硬化治疗有症状的良性非寄生虫性肝囊肿的1年结果,乙醇暴露时间最长为10分钟。在1995年至1999年期间,对9例患者(8名女性和1名男性)的15个有症状的肝囊肿进行了10分钟的乙醇暴露治疗。采用超声引导穿刺结合荧光透视法放置导管。酒精硬化治疗使用的乙醇最大体积为囊肿体积的10%,浓度为96%,且绝不超过100毫升。随访时,对患者进行肝功能检查、超声或CT检查、临床检查,并由胃肠外科医生进行访谈。纳入了7例患者(6名女性和1名男性;年龄范围44 - 61岁,中位年龄58岁)的10个囊肿,这些患者的随访时间至少为1年。最初的囊肿体积为30 - 4110毫升(中位体积392毫升)。在12 - 47个月(中位23个月)的随访期后,囊肿体积为0 - 523毫升(中位体积21.5毫升),中位囊肿体积减少了95%(p<0.005)。所有患者的临床症状均得到缓解。除疼痛外,未观察到并发症。仅采用单次治疗且乙醇暴露时间最长为10分钟的硬化治疗是有症状肝囊肿的一种有效治疗方法。

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