Rocha Paulo N, Plumb Troy J, Coffman Thomas M
Department of Medicine, Division of Nephrology, Duke University and Durham VA Medical Centers, Building 6/Nephrology, 508 Fulton Street, Durham, NC 27705, USA.
Springer Semin Immunopathol. 2003 Sep;25(2):215-27. doi: 10.1007/s00281-003-0132-4.
Eicosanoids are a family of lipid mediators derived from the metabolism of arachidonic acid. Eicosanoids, such as prostanoids and leukotrienes, have a wide range of biological actions including potent effects on inflammation and immunity. It has been almost 20 years since the first reports emerged suggesting a role for eicosanoids in transplantation. Since then, a number of functions have been ascribed to these mediators, ranging from immunomodulation to regulation of allograft hemodynamics. In this review, we will highlight the effects of eicosanoids in transplantation, focusing particularly on evidence provided by gene targeting studies. In the future, pharmacological manipulation of eicosanoids and their receptors may provide a novel approach for controlling inflammation and promoting allograft acceptance.
类二十烷酸是一类由花生四烯酸代谢产生的脂质介质。类二十烷酸，如前列腺素和白三烯，具有广泛的生物学作用，包括对炎症和免疫的强大影响。自首次报道类二十烷酸在移植中发挥作用以来，已经过去了近20年。从那时起，这些介质被赋予了许多功能，从免疫调节到同种异体移植物血流动力学的调节。在这篇综述中，我们将重点介绍类二十烷酸在移植中的作用，特别关注基因靶向研究提供的证据。未来，对类二十烷酸及其受体的药理学操纵可能为控制炎症和促进同种异体移植物接受提供一种新方法。
